Other Week 6 college football lines of note include No. Should you back Williams, the current favorite to win the Heisman Trophy and become only the second two-time winner of the award in college football history, and his Trojans teammates in Week 6 college football bets? USC is a 21.5-point favorite in the latest Week 6 college football odds via SportsLine consensus. ET in the final Saturday game of the Week 6 college football schedule. While many of the noon ET games on the Week 6 college football schedule are getting a bulk of the attention, the week also ends with one of the most exciting players in college football in recent memory.